--- title: Shockwave Therapy Clinical Evidence for Wound Treatment | CuraMedix description: A list of articles that offer insights and clinical evidence into the uses and benefits of shockwave and EMTT therapy in the field of wound treatment. --- - [CuraMedix Providers: Insiders' Exchange Login](https://www.curamedix.com/partner-portal-login-page?hsLang=en) - ** [![curamedix_logo_color](https://www.curamedix.com/hubfs/Website%202019/Logos/curamedix_logo_color.svg "curamedix_logo_color")](https://www.curamedix.com?hsLang=en) [![curamedix_logo_color](https://www.curamedix.com/hubfs/Website%202019/Logos/curamedix_logo_color.svg "curamedix_logo_color")](https://www.curamedix.com?hsLang=en) **Redefine Patient Care** Is your practice leading the way with innovative treatment options? #### Featured Resource What is shockwave and what makes it so effective? “The Art of Shockwave” white paper reveals the in-depth science behind the technology. 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[![Dig in Now](https://no-cache.hubspot.com/cta/default/4232994/0ad47fe2-5d69-4482-acea-98c31886035b.png)](https://cta-redirect.hubspot.com/cta/redirect/4232994/0ad47fe2-5d69-4482-acea-98c31886035b) # Shockwave Therapy Clinical Evidence: Advanced Wound Healing ## Clinical Data: Acoustic Pressure Waves in Medicine These articles offer insight into the uses and benefits of non-surgical approaches to include radial pressure wave (EPAT**®**) and focused shockwave (ESWT) in the field of wound treatment. ***Please note: **Some of the information contained in the articles listed may pertain to products, indications for use of products and/or treatments/ procedures that are only available outside the United States and have not been approved or cleared for marketing by the United States Food & Drug Administration. * Filter All Wounds Diabetic and Non-Diabetic Ulcers Burns Scars Lymphedema Management ## Wounds [#### Extracorporeal Shock Wave Therapy for Hypertrophic Scars Apirag Chuangsuwanich, Natthapong Kongkunnavat, Malika Kamanamool, Gulradar Maipeng, Nanticha Kamanamool, Warangkana Tonaree. Arch Plastic Surgery (2022) ](https://pubmed.ncbi.nlm.nih.gov/35919551/) [#### Extracorporeal Shockwave Therapy for Chronic Venous Ulcers: A Randomized Controlled Tria Parisa Taheri, Morteza Shahbandari, Mehrnoosh Parvaresh, Babak Vahdatpour. Galen Med J. (2021) ](https://pubmed.ncbi.nlm.nih.gov/35434156/) [#### Shock Wave Therapy for Wound Healing and Scar Treatmen Peter Moortgat, Mieke Anthonissen, Ulrike Van Daele, Jill Meirte, Tine Vanhullebusch, Koen Maertens, Luc Teot, Thomas A. Mustoe, Esther Middelkoop, Gerd G. Gauglitz. Textbook on Scar Management: State of the Art Management and Emerging Technologies (2020) ](https://pubmed.ncbi.nlm.nih.gov/36351147/) [#### Shock Wave Therapy for Wound Healing and Scar Treatment Textbook on Scar Management: State of the Art Management and Emerging Technologies (2020) ](https://www.ncbi.nlm.nih.gov/books/NBK586112/#:~:text=Shock%20Wave%20Therapy%20(SWT)%20meets,used%20in%20an%20outpatient%20setting) [#### Effects of the extracorporeal shock wave therapy on the skin: an experimental study Thayná Melo de Lima Morais, Patrícia Froes Meyer, Liliane Santos de Vasconcellos, Lasers Med Science (2018) ](https://pubmed.ncbi.nlm.nih.gov/30109536/#:~:text=The%20results%20showed%20that%20ESWT,control%2C%20non%2Dtreated%20group.) [#### The lacrimal gland: development, wound repair and regeneration Yupeng Yao, Yan Zhang. Wound Repair and Regeneration. (2017) ](https://pubmed.ncbi.nlm.nih.gov/28353146/) [#### Defocused Shock Wave Therapy for Chronic Soft Tissue Wounds in the Lower Limbs: A Pilot Study Porso M, Loreti S, Nusca SM, Luziatelli S, Caccia D, Taborri G, Trischitta D, Taurino M, Padua L, Saraceni VM, Vulpiani MC, Vetrano M. Ultrasound in Medicine & Biology (2017) ](https://www.ncbi.nlm.nih.gov/pubmed/27745716) [#### Effect of extracorporeal shock wave therapy on scar pain in burn patients Yoon Soo Cho, So Young Joo, Huisong Cui, Sung-Rae Cho, Haejun Yim, Cheong Hoon Seo Medicine (2016) ](https://pubmed.ncbi.nlm.nih.gov/27512886/) [#### Immediate Dose-Response Effect Of High-Energy Versus Low-Energy Extracorporeal Shock Wave Therapy On Cutaneous Microcirculation Robert Kraemer, Heiko Sorg, Vinzent Forstmeier, Karsten Knobloch, Eirini Liodaki, Felix Hagen Stang, Peter Mailaender, Tobias Kisch Ultrasound in Med. & Biol. (2016) ](https://pubmed.ncbi.nlm.nih.gov/27662701/) [#### Extracorporeal Shock Wave Therapy for Injection Site Panniculitis in Multiple Sclerosis Patients Marco Stieger 1, Jean-Paul Schmid, Nikhil Yawalkar, Thomas Hunziker Dermatology (2015) ](https://pubmed.ncbi.nlm.nih.gov/25502016/) [#### Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling Naths Grazia Sukubo, Elisabetta Tibalt, Stefano Respizzi, Massimo Locati, M Cristina d’Agostino. International Journal of Surgery. (2015) ](https://pubmed.ncbi.nlm.nih.gov/26291028/) [#### Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation Anna M. Weihs, Christiane Fuchs, Andreas H. Teuschl, Joachim Hartinger, Paul Slezak, Rainr Mittermayr, Heinz Redl, Wolfgang G. Junger, Harald H. Sitte, Dominik Runzler. Journal of Biological Chemistry. (2014) ](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175346/) [#### Mechanotherapy: revisiting physical therapy and recruiting mechanobiology for a new era in medicine Chenyu Huang, Johannes Hofeld, Wolfgang Schaden, Dennis Orgill, Rei Ogawa. Trends in Molecular Medicine. (2013) ](https://pubmed.ncbi.nlm.nih.gov/23790684/) [#### The biological effects of extracorporeal shock wave therapy (eswt) on tendon tissue Angela Notarnicola, Biagio Moretti. Muscles, Ligaments, and Tendons Journal. (2012) ](https://pubmed.ncbi.nlm.nih.gov/23738271/) [#### Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice: a critical role of endothelial nitric oxide synthase Hayashi D, Kawakami K, Ito K, Ishii K, Tanno H, Imai Y, Kanno E, Maruyama R, Shimokawa H, Tachi M. Wound Repair and Regeneration (2012) ](https://www.ncbi.nlm.nih.gov/pubmed/23110611) [#### Extracorporeal shock wave therapy (ESWT) for wound healing: technology, mechanisms, and clinical efficacy Rainer Mittermayr, Vlado Antonic, Joachim Hartinger, Hanna Kaufman, Heinz Redl, Luc Teot, Alexander Stojadinovic, Wolfgang Schaden. Wound Repair and Regeneration. (2012) ](https://pubmed.ncbi.nlm.nih.gov/22642362/) [#### Extracorporeal Shock Wave Therapy Induces Therapeutic Lymphangiogenesis in a Rat Model of Secondary Lymphoedema F. Serizawa, K. Ito, M. Matsubara, A. Sato, H. Shimokawa, S. Satomi. European Journal of Vascular & Endovasular Surgery. (2011) ](https://www.sciencedirect.com/science/article/pii/S1078588411001328) [#### Extracorporeal shock wave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis Rainer Mittermayr, Joachim Hartinger, Vlado Antonic, Alexandra Meinl, Sabine Pfiefer, Alexander Stojadinovic, Wolfgang Schaden, Heinz Redl. Annals of Surgery. (2011) ](https://pubmed.ncbi.nlm.nih.gov/21372687/) [#### The wound‐healing effects of a next‐generation anti‐biofilm silver Hydrofiber wound dressing on deep partial‐thickness wounds using a porcine model Stephen Davis, Jie Li, Joel Gil, Jose Valdes, Michael Solis, Alex Higa, Philip Bowler. International Wound Journal. (2009) ](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949536/) [#### Extracorporeal shock waves down-regulate the expression of interleukin-10 and tumor necrosis factor-alpha in osteoarthritic chondrocytes Biagio Moretti, Florenzo Iannone, Angela Notarnicola, Giovanni Lapadula, Lorenzo Moretti, Vittorio Patella, Raffaele Garofalo. BMC Musculoskeletal Disorders. Moretti, B. et al. (2008) ](https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-9-16) [#### Antibacterial effects of extracorporeal shock waves Ludger Gerdesmeyer, Christoff von Eiff, Carsten Horn, Mark Henne, Michaela Roessner, Peter Diehl, Hans Gollwitzer. Ultrasound in medicine and biology. (2005) ](https://www.sciencedirect.com/science/article/abs/pii/S0301562904002339) ## Diabetic and Non-Diabetic Ulcers [#### Radial extracorporeal shock wave therapy in a patient with decubitus ulcer after spinal cord injury: a case report. Nan Kang, Xiaotong Yu, Yuewen Ma. Am J Transl res (2020). ](https://pubmed.ncbi.nlm.nih.gov/32509203/) [#### Indications and application of extracorporeal shockwave therapy Sune Moller Skov-Jeppesen, Ronja Niemann Lundrup, Peter Bille Juul Ladegaard, Jonas Mortensen, Mia Dahl Sorensen, Lars Lund. Ugeskr Larger (2019) ](https://pubmed.ncbi.nlm.nih.gov/30821242/) [#### Improved Healing of Diabetic Foot Ulcer Upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave Shunhao Wang, Chunyang Yin, Xiaoguang, Anyi Guo, Xiaodong Chen, Sijin Liu, Yajun Liu. Oxid Med Cell Longev.(2019) ](https://pubmed.ncbi.nlm.nih.gov/31485296/) [#### Diabetic foot ulcer treatment with focused shockwave therapy: two multicentre, prospective, controlled, double-blinded, randomised phase III clinical trials Robert Snyder, Robert Galiano, Perry Mayer, Lee C Rogers, Oscar Alvarez, Sanuwave Trial Investigators. J Wound Care (2018) ](https://pubmed.ncbi.nlm.nih.gov/30557108/) [#### Extracorporeal Shock Wave Therapy for Digital Ulcers of Systemic Sclerosis: A Phase 2 Pilot Study. Saito S, Ishii T, Kamogawa Y, Watanabe R, Shirai T, Fujita Y, Shirota Y, Fujii H, Ito K, Shimokawa H, Yamaguchi T, Kawaguchi Y, Harigae H. Tohoku Journal for Experimental Medicine (2016) ](https://www.ncbi.nlm.nih.gov/pubmed/26686380) [#### Extracorporeal shockwave therapy in the treatment of chronic diabetic foot ulcers: a prospective randomised trial Jeppesen SM, Yderstraede KB, Rasmussen BS, Hanna M, Lund L. Journal of Wound Care (2016) ](https://www.ncbi.nlm.nih.gov/pubmed/27827284) [#### Extracorporeal shockwave therapy in diabetic foot ulcers International Journal of Surgery Wang, Ching-Jena,b,*; Cheng, Jai-Honga,c; Kuo, Yur-Rena,d; Schaden, Wolfgange,f; Mittermayr, Rainere,f International Journal of Surgery (2015) ](https://journals.lww.com/international-journal-of-surgery/Fulltext/2015/12020/Extracorporeal_shockwave_therapy_in_diabetic_foot.19.aspx) [#### Long-term outcomes of extracorporeal shockwave therapy for chronic foot ulcers Wang CJ, Wu CT, Yang YJ, Liu RT, Kuo YR. Journal of Surgery Research (2014) ](https://www.ncbi.nlm.nih.gov/pubmed/24721603) [#### Efficacy of shock wave therapy on chronic diabetic foot ulcer: A single-blinded randomized controlled clinical trial Omar MT, Alghadir A, Al-Wahhabi KK, Al-Askar AB Diabetes Research and Clinical Practice (2014) ](https://www.ncbi.nlm.nih.gov/pubmed/?term=Efficacy+of+shock+wave+therapy+on+chronic+diabetic+foot+ulcer%3A+A+single-blinded+randomized+controlled+clinical+trial) [#### Extracorporeal shock wave therapy in the treatment of a non-healing chronic venous leg ulcer M Stieger, J-P Schmid, S Bajrami, T Hunziker Hautarzt (2013) ](https://pubmed.ncbi.nlm.nih.gov/23322179/) [#### Case study: shock waves treatment of diabetic gangrene Jankovic D. International Wound Journal (2011) ](https://www.ncbi.nlm.nih.gov/pubmed/21385321) [#### The management of neuropathic ulcers of the foot in diabetes by shock wave therapy Moretti B, Notarnicola A, Maggio G, Moretti L, Pascone M, Tafuri S, Patella V. BMC Musculoskeletel Disorders (2009) ](https://www.ncbi.nlm.nih.gov/pubmed/19473538) [#### Extracorporeal Shockwave Therapy for Chronic Venous Ulcers: A Randomized Controlled Trial Parisa Taheri, Morteza Shahbandari, Mehrnoosh Parvaresh, Babak Vahdatpour. Galen Med J. (2021) ](https://pubmed.ncbi.nlm.nih.gov/35434156/) ## Burns [#### Effect of extracorporeal shock wave therapy for burn scar regeneration: A prospective, randomized, double-blinded study Seung Yeol Lee, So Young Joo, Yoon Soo Cho, Gi Yeun Hur, Cheong Hoon Seo. Burns (2020) ](https://pubmed.ncbi.nlm.nih.gov/32917473/) [#### Extracorporeal shock wave therapy role in the treatment of burn patients. A systematic literature review Jorge Aguilera-Saez, Pablo Munoz, Jordi Serracanta, Alejandra Monte, Juan P Barret. Burns (2020) ](https://pubmed.ncbi.nlm.nih.gov/31387804/) [#### The clinical utility of extracorporeal shock wave therapy for burn pruritus: A prospective, randomized, single-blind study So Young Joo, Yoon Soo Cho, Cheong Hoon Seo, Burns (2017) ](https://pubmed.ncbi.nlm.nih.gov/29029857/) [#### Effect of extracorporeal shock wave therapy on scar pain in burn patients: A prospective, randomized, single-blind, placebo-controlled study Yoon Soo Cho, So Young Joo, Huisong Cui, Sung-Rae Cho, Haejun Yim, Cheong Hoon Seo. Medicine (Baltimore) (2016) ](https://pubmed.ncbi.nlm.nih.gov/27512886/) ## Scars [#### Shock Wave Therapy for Wound Healing and Scar Treatment Peter Moortgat, Mieke Anthonissen, Ulrike Van Daele, Jill Meirte, Tine Vanhullebusch, Koen Maertens, Luc Teot, Thomas A. Mustoe, Esther Middelkoop, Gerd G. Gauglitz. Textbook on Scar Management: State of the Art Management and Emerging Technologies (2020) ](https://pubmed.ncbi.nlm.nih.gov/36351147/) [#### Effects of Preoperative Extracorporeal Shockwave Therapy on Scar Formation-A Pilot Study on 24 Subjects Undergoing Abdominoplasty Surgery Elisabeth Russe, Gottfried Wechselberger, Karl Schwaiger, Klemens Heinrich, Michaela Hladik, Heike Traintinger. Lasers Surgery Medicine (2019) ](https://pubmed.ncbi.nlm.nih.gov/31033008/) [#### Extracorporeal Shock Wave Therapy Alters the Expression of Fibrosis-Related Molecules in Fibroblast Derived from Human Hypertrophic Scar Hui Song Cui 1, A Ram Hong 2, June-Bum Kim 3, Joo Hyang Yu 4, Yoon Soo Cho 5, So Young Joo 6, Cheong Hoon Seo 7 Int. J. Mol. Sci. (2018) ](https://pubmed.ncbi.nlm.nih.gov/29301325/) [#### Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring Meilang Xue, Christopher J Jackson. Advances in Wound Care (New Rochelle). (2015) ](https://pubmed.ncbi.nlm.nih.gov/25785236/) ## Lymphedema Management [#### Management of Lymphedema Rudiger G H Baumeister. Leitlinie: Diagnostik und Therapie der Lymphodeme AWMF Reg.-Nr. 058-001. (2017). ](https://pubmed.ncbi.nlm.nih.gov/29207421/) [#### Extracorporeal Shock Wave Therapy Induces Therapeutic Lymphangiogenesis in a Rat Model of Secondary Lymphoedema F. Serizawa, K. Ito, M. Matsubara, A. Sato, H. Shimokawa, S. Satomi. European Journal of Vascular & Endovasular Surgery. (2011) ](https://www.sciencedirect.com/science/article/pii/S1078588411001328) [#### Extracorporeal shock wave therapy ameliorates secondary lymphedema by promoting lymphangiogenesis Masayuki Kubo, Tao Sheng Li, Takahiro Kamota, Mako Ohshima, Bungo Shirasawa, Kimikazu Hamano. Journal of Vascular Surgery. (2010) ](https://okayama.elsevierpure.com/en/publications/extracorporeal-shock-wave-therapy-ameliorates-secondary-lymphedem) [#### Changes of tissue fluid hyaluronan (hyaluronic acid) in peripheral lymphedema N F Liu, L R Zhang. Lymphology. 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